Article

Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in mice with the common human variant in the μ-opioid receptor, Oprm1 A118G

2025-08-18

Abstract excerpt

<title>Abstract</title> Opioid Use Disorder (OUD) is a multifaceted neuropsychiatric disease that can arise from genetic, environmental, and neurobiological factors. The OPRM1 A118G single nucleotide polymorphism (rs1799971) encodes an N40D variant in the µ-opioid receptor (MOR) and is linked to increased risk of opioid and other drug dependencies, though its exact mechanism remains unknown. With the ongoing o...

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Literature Corpus work: 18ab6cc3-8f42-5fc1-b84d-d7e93538a606
DOI: 10.21203/rs.3.rs-7199524/v1

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