Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human μ-opioid receptor variant Oprm1 A118G.

doi:10.1038/s41467-026-75723-0

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Article

Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human μ-opioid receptor variant Oprm1 A118G.

Nature communications - 23 Jul 2026

Xie Yihan, Leonard Anna K, Guessoum Omar, Windisch Kyle A, Schug Johnathan, El-Mekkoussi Hilana, Jo Adrienne, Cullen D Kacy, Kaestner Klaus H, Blendy Julie A

Abstract excerpt

Opioid Use Disorder (OUD) is a complex neuropsychiatric condition shaped by multiple factors including genetics. The A118G single-nucleotide polymorphism (rs1799971) in the µ-opioid receptor gene (OPRM1) has been associated with heightened risk for opioid and other substance dependencies, but the molecular basis of this effect remains unclear. Importantly, mice with the orthologous SNP, Oprm1 A112G, recapitulate...

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PMID: 42637754
DOI: 10.1038/s41467-026-75723-0
PMCID: PMC13503859

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OPRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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