Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats.

doi:10.1038/s41380-025-02922-4

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats.

Molecular psychiatry - 1 Aug 2025

Kuhn Brittany N, Cannella Nazzareno, Chitre Apurva S, Nguyen Khai-Minh H, Cohen Katarina, Chen Denghui, Peng Beverly, Ziegler Kendra S, Lin Bonnie, Johnson Benjamin B, Missfeldt Sanches Thiago, Crow Ayteria D, Lunerti Veronica, Gupta Arkobrato, Dereschewitz Eric, Soverchia Laura, Hopkins Jordan L, Roberts Analyse T, Ubaldi Massimo, Abdulmalek Sarah, Kinen Analia, Hardiman Gary, Chung Dongjun, Polesskaya Oksana, Solberg Woods Leah C, Ciccocioppo Roberto, Kalivas Peter W, Palmer Abraham A

Abstract excerpt

The increased prevalence of opioid use disorder (OUD) makes it imperative to disentangle the biological mechanisms contributing to individual differences in OUD vulnerability. OUD shows strong heritability, however genetic variants contributing to vulnerability remain poorly defined. We performed a genome-wide association study using over 850 male and female heterogeneous stock (HS) rats to identify genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Outbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Heroin Dependence

Share to Opioid-Related Disorders

Share to Polymorphism, Single Nucleotide

Share to Rats

Source

Open in PubMed Open full text

Identifiers

PMID: 40000848
DOI: 10.1038/s41380-025-02922-4
PMCID: PMC12240846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats.PMID 40000848Read ↗

Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred ratsSemantic proximity Read ↗

A multi-symptomatic model of heroin use disorder in rats reveals distinct behavioral profiles and neuronal correlates of heroin vulnerability versus resiliencySemantic proximity Read ↗

Genetic Architecture of Addiction-Relevant Behaviors in Outbred Sprague-Dawley Rats Reveals Loci for Anxiety-Like and Nociceptive Traits.Semantic proximity Read ↗

Genetic addiction risk score (GARS) ™, a predictor of vulnerability to opioid dependence.Semantic proximity Read ↗

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.Semantic proximity Read ↗

Individual differences in oxycodone addiction-like behaviors in a large cohort of heterogeneous stock (HS) ratsSemantic proximity Read ↗

Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction.Semantic proximity Read ↗

Network-Based Discovery of Opioid Use Vulnerability in Rats Using the Bayesian Stochastic Block ModelSemantic proximity Read ↗

Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors.Semantic proximity Read ↗

Genetic Vulnerability to Opioid Addiction.Semantic proximity Read ↗

Molecular genetic underpinnings of human substance abuse vulnerability: likely contributions to understanding addiction as a mnemonic process.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.