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Article

Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype.

Nature neuroscience - 1 Sept 2006

Heurteaux Catherine, Lucas Guillaume, Guy Nicolas, El Yacoubi Malika, Thümmler Susanne, Peng Xiao-Dong, Noble Florence, Blondeau Nicolas, Widmann Catherine, Borsotto Marc, Gobbi Gabriella, Vaugeois Jean-Marie, Debonnel Guy, Lazdunski Michel

Abstract excerpt

Depression is a devastating illness with a lifetime prevalence of up to 20%. The neurotransmitter serotonin or 5-hydroxytryptamine (5-HT) is involved in the pathophysiology of depression and in the effects of antidepressant treatments. However, molecular alterations that underlie the pathology or treatment of depression are still poorly understood. The TREK-1 protein is a background K+ channel regulated by...

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PMID: 16906152
DOI: 10.1038/nn1749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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