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Article

Functional characterization of putative cholesterol binding sequence (CRAC) in human type-1 cannabinoid receptor.

Journal of neurochemistry - 1 Mar 2011

Oddi Sergio, Dainese Enrico, Fezza Filomena, Lanuti Mirko, Barcaroli Daniela, De Laurenzi Vincenzo, Centonze Diego, Maccarrone Mauro

Abstract excerpt

Endocannabinoid signaling modulates a variety of neuroinflammatory and neurodegenerative diseases, mainly through the activation of type-1 and type-2 (CB(1)R and CB(2)R) cannabinoid receptors. CB(1)R is negatively regulated by membrane cholesterol, while CB(2)R is unaffected. Here, we identified...

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Source

Identifiers

PMID: 21214565
DOI: 10.1111/j.1471-4159.2010.07041.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21214565-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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