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Article

Endogenous truncated TrkB.T1 receptor regulates neuronal complexity and TrkB kinase receptor function in vivo.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Jan 2009

Carim-Todd Laura, Bath Kevin G, Fulgenzi Gianluca, Yanpallewar Sudhirkumar, Jing Deqiang, Barrick Colleen A, Becker Jodi, Buckley Hannah, Dorsey Susan G, Lee Francis S, Tessarollo Lino

Abstract excerpt

Pathological or in vitro overexpression of the truncated TrkB (TrkB.T1) receptor inhibits signaling through the full-length TrkB (TrkB.FL) tyrosine kinase receptor. However, to date, the role of endogenous TrkB.T1 is still unknown. By studying mice lacking the truncated TrkB.T1 isoform but retaining normal spatiotemporal expression of TrkB.FL, we have analyzed TrkB.T1-specific physiological functions and its...

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Identifiers

PMID: 19158294
DOI: 10.1523/JNEUROSCI.5060-08.2009
PMCID: PMC2719435

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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