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MeCP2 represses the activity of topoisomerase IIβ in long neuronal genes

1 Dec 2023

Abstract excerpt

A unique signature of neurons is the high expression of the longest genes in the genome. These genes have essential neuronal functions, and disruption of their expression has been implicated in neurological disorders. DNA topoisomerases resolve DNA topological constraints and facilitate neuronal long gene expression. Conversely, the Rett syndrome protein, methyl-CpG-binding protein 2 (MeCP2), can...

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PMID: 38096051
DOI: 10.1016/j.celrep.2023.113538

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