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Article

Topoisomerases facilitate transcription of long genes linked to autism.

Nature - 5 Sept 2013

King Ian F, Yandava Chandri N, Mabb Angela M, Hsiao Jack S, Huang Hsien-Sung, Pearson Brandon L, Calabrese J Mauro, Starmer Joshua, Parker Joel S, Magnuson Terry, Chamberlain Stormy J, Philpot Benjamin D, Zylka Mark J

Abstract excerpt

Topoisomerases are expressed throughout the developing and adult brain and are mutated in some individuals with autism spectrum disorder (ASD). However, how topoisomerases are mechanistically connected to ASD is unknown. Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-dependently reduces the expression of extremely long genes in mouse and human neurons, including nearly all genes that are...

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Source

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Identifiers

PMID: 23995680
DOI: 10.1038/nature12504
PMCID: PMC3767287

Genes

TOP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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