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Article

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome.

Nature - 4 Jun 2015

Gabel Harrison W, Kinde Benyam, Stroud Hume, Gilbert Caitlin S, Harmin David A, Kastan Nathaniel R, Hemberg Martin, Ebert Daniel H, Greenberg Michael E

Abstract excerpt

Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder with features of autism. MECP2 encodes a methyl-DNA-binding protein that has been proposed to function as a transcriptional repressor, but despite numerous mouse studies examining neuronal gene expression in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25762136
DOI: 10.1038/nature14319
PMCID: PMC4480648

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25762136-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Disruption of DNA-methylation-dependent long gene repression in Rett syndrome.PMID 25762136Read ↗

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DNA methylation in the gene body influences MeCP2-mediated gene repression.Semantic proximity Read ↗

MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes.Semantic proximity Read ↗

MeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal GenesSemantic proximity Read ↗

MeCP2 dysfunction in Rett syndrome and related disorders.Semantic proximity Read ↗

The molecular pathology of Rett syndrome: synopsis and update.Semantic proximity Read ↗

Gene length matters in neurons.Semantic proximity Read ↗

MECP2 Dysfunction in Rett Syndrome: Molecular Mechanisms, Multisystem Pathology, and Emerging Therapeutic Strategies.Semantic proximity Read ↗

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice.Semantic proximity Read ↗

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