Article
Disruption of DNA-methylation-dependent long gene repression in Rett syndrome.
Nature - 4 Jun 2015
Gabel Harrison W, Kinde Benyam, Stroud Hume, Gilbert Caitlin S, Harmin David A, Kastan Nathaniel R, Hemberg Martin, Ebert Daniel H, Greenberg Michael E
Abstract excerpt
Disruption of the MECP2 gene leads to Rett syndrome (RTT), a severe neurological disorder with features of autism. MECP2 encodes a methyl-DNA-binding protein that has been proposed to function as a transcriptional repressor, but despite numerous mouse studies examining neuronal gene expression in Mecp2 mutants, no clear model has emerged for how MeCP2 protein regulates transcription. Here we identify a...
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