Article

MeCP2 Interacts with the Super Elongation Complex to Regulate Transcription

2024-07-01

Abstract excerpt

Loss-of-function mutations in methyl-CpG binding protein 2 ( MECP2 ) cause Rett syndrome, a postnatal neurodevelopmental disorder that occurs in ∼1/10,000 live female births. MeCP2 binds to methylated cytosines across genomic DNA and recruits various partners to regulate gene expression. MeCP2 has been shown to repress transcription in vitro and interacts with co-repressors such as the Sin3A and NCoR complexes....

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Literature Corpus work: ba558bad-fd37-5976-919a-7538b14c9b91
DOI: 10.1101/2024.06.30.601446

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