Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Parallelized engineering of mutational models using piggyBac transposon delivery of CRISPR libraries.

Cell reports methods - 22 Jan 2024

Nuttle Xander, Burt Nicholas D, Currall Benjamin, Moysés-Oliveira Mariana, Mohajeri Kiana, Bhavsar Riya, Lucente Diane, Yadav Rachita, Tai Derek J C, Gusella James F, Talkowski Michael E

Abstract excerpt

New technologies and large-cohort studies have enabled novel variant discovery and association at unprecedented scale, yet functional characterization of these variants remains paramount to deciphering disease mechanisms. Approaches that facilitate parallelized genome editing of cells of interest or induced pluripotent stem cells (iPSCs) have become critical tools toward this goal. Here, we developed an approach...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Gene Editing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genomics

Share to Induced Pluripotent Stem Cells

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 38091988
DOI: 10.1016/j.crmeth.2023.100672
PMCID: PMC10831954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Parallelized engineering of mutational models using piggyBac transposon delivery of CRISPR libraries.PMID 38091988Read ↗

Parallelized engineering of mutational models using piggyBac transposon delivery of CRISPR librariesSemantic proximity Read ↗

Advances in functional genetic screening with transposons and CRISPR/Cas9 to illuminate cancer biology.Semantic proximity Read ↗

Site-specific integration of transposon via engineered piggyBac transposaseSemantic proximity Read ↗

Prime Editing Driven Functional Genomics: Bridging Genotype to Phenotype in the Post-Genomic Era.Semantic proximity Read ↗

PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in miceSemantic proximity Read ↗

piggyBac-mediated genomic integration of linear dsDNA-based library for deep mutational scanning in mammalian cells.Semantic proximity Read ↗

Precision genome-editing with CRISPR/Cas9 in human induced pluripotent stem cellsSemantic proximity Read ↗

Editing stem cell genomes at scale to measure variant effects in diverse cell and genetic contextsSemantic proximity Read ↗

Genome-wide Genetic Mutations Accumulated in Pigs Genome-edited for Xenotransplantation and Their Filial Generation.Semantic proximity Read ↗

Efficient gene knockout and genetic interactions: the IN4MER CRISPR/Cas12a multiplex knockout platformSemantic proximity Read ↗

CRISPR Del/Rei: A simple, flexible, and efficient pipeline for scarless genome editingSemantic proximity Read ↗

Optimized Prime Editing of Human Induced Pluripotent Stem Cells to Efficiently Generate Isogenic Models of Mendelian Diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.