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Article

White Matter Abnormalities Track Disease Progression in PSEN1 Autosomal Dominant Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2016

Sánchez-Valle Raquel, Monté Gemma C, Sala-Llonch Roser, Bosch Beatriz, Fortea Juan, Lladó Albert, Antonell Anna, Balasa Mircea, Bargalló Nuria, Molinuevo José Luis

Abstract excerpt

PSEN1 mutations are the most frequent cause of autosomal dominant Alzheimer's disease (ADAD), and show nearly full penetrance. There is presently increasing interest in the study of biomarkers that track disease progression in order to test therapeutic interventions in ADAD. We used white mater (WM) volumetric characteristics and diffusion tensor imaging (DTI) metrics to investigate correlations with the...

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PMID: 26923015
DOI: 10.3233/JAD-150899

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PSEN1

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