Article
Characterizing the Clinical Features and Atrophy Patterns of MAPT-Related Frontotemporal Dementia With Disease Progression Modeling.
Neurology - 31 Aug 2021
Young Alexandra L, Bocchetta Martina, Russell Lucy L, Convery Rhian S, Peakman Georgia, Todd Emily, Cash David M, Greaves Caroline V, van Swieten John, Jiskoot Lize, Seelaar Harro, Moreno Fermin, Sanchez-Valle Raquel, Borroni Barbara, Laforce Robert, Masellis Mario, Tartaglia Maria Carmela, Graff Caroline, Galimberti Daniela, Rowe James B, Finger Elizabeth, Synofzik Matthis, Vandenberghe Rik, de Mendonça Alexandre, Tagliavini Fabrizio, Santana Isabel, Ducharme Simon, Butler Chris, Gerhard Alex, Levin Johannes, Danek Adrian, Otto Markus, Sorbi Sandro, Williams Steven C R, Alexander Daniel C, Rohrer Jonathan D
Abstract excerpt
BACKGROUND AND OBJECTIVE: Mutations in the MAPT gene cause frontotemporal dementia (FTD). Most previous studies investigating the neuroanatomical signature of MAPT mutations have grouped all different mutations together and shown an association with focal atrophy of the temporal lobe. The variability in atrophy patterns between each particular MAPT mutation is less well-characterized. We aimed to investigate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.