Article
Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2025
Bouzigues Arabella, Du Vincent Le, Joulot Matthieu, Peysson Ninon, Houot Marion, Béranger Benoît, Russell Lucy L, Foster Phoebe H, Ferry-Bolder Eve, van Swieten John C, Jiskoot Lize, Seelaar Harro, Sanchez-Valle Raquel, Laforce Robert, Graff Caroline, Galimberti Daniela, Vandenberghe Rik, de Mendonça Alexandre, Tiraboschi Pietro, Santana Isabel, Gerhard Alexander, Levin Johannes, Sorbi Sandro, Otto Markus, Bertoux Maxime, Lebouvier Thibaud, Ducharme Simon, Butler Chris R, Ber Isabelle Le, Finger Elizabeth, Tartaglia Maria Carmela, Masellis Mario, Rowe James B, Synofzik Matthis, Moreno Fermin, Borroni Barbara, Rohrer Jonathan D, Migliaccio Raffaella
Abstract excerpt
INTRODUCTION: Microtubule-associated protein tau (MAPT) mutations cause frontotemporal dementia (FTD), characterised by behavioural, language, and motor impairments due to brain connectivity disruptions. We investigated structural and functional connectivity in 86 mutation carriers and 272 controls to map connectivity changes at different disease stages. METHODS: The CDR Dementia Staging Instrument plus National...
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