Article
Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B.
Science advances - 15 Dec 2023
Pal Prosenjit, Taylor Matthew, Lam Pui Yiu, Tonelli Francesca, Hecht Chloe A, Lis Pawel, Nirujogi Raja S, Phung Toan K, Yeshaw Wondwossen M, Jaimon Ebsy, Fasimoye Rotimi, Dickie Emily A, Wightman Melanie, Macartney Thomas, Pfeffer Suzanne R, Alessi Dario R
Abstract excerpt
We demonstrate that the Parkinson's VPS35[D620N] mutation alters the expression of ~220 lysosomal proteins and stimulates recruitment and phosphorylation of Rab proteins at the lysosome. This recruits the phospho-Rab effector protein RILPL1 to the lysosome where it binds to the lysosomal integral membrane protein TMEM55B. We identify highly conserved regions of RILPL1 and TMEM55B that interact and design...
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