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Article

VPS35 mutation inhibits PINK1/parkin-mediated mitophagy via increased LRRK2 kinase activity.

Brain : a journal of neurology - 7 Jul 2026

Manders Liselot, Heyninck Thibaut, Imberechts Dorien, Holst Bjørn, Krüger Rejko, Vandenberghe Wim

Abstract excerpt

The p.D620N mutation in VPS35 causes an autosomal dominant form of Parkinson's disease via mechanisms that are poorly understood. PINK1 and parkin, two proteins whose loss-of-function underlies autosomal recessive Parkinson's disease, cooperate to mediate mitophagy, a quality control pathway for selective elimination of damaged mitochondria. PINK1/parkin-mediated mitophagy is disrupted by LRRK2 mutations, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41164908
DOI: 10.1093/brain/awaf414
PMCID: PMC13337223

Genes

VPS35
PINK1
RAB10
PPM1H

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Research trail→

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VPS35 mutation inhibits PINK1/parkin-mediated mitophagy via increased LRRK2 kinase activity.PMID 41164908Read ↗

Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons.Semantic proximity Read ↗

Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy.Semantic proximity Read ↗

VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.Semantic proximity Read ↗

VPS35, the Retromer Complex and Parkinson's Disease.Semantic proximity Read ↗

VPS35 and retromer dysfunction in Parkinson's disease.Semantic proximity Read ↗

VPS35 and the mitochondria: Connecting the dots in Parkinson's disease pathophysiologySemantic proximity Read ↗

Parkinson’s disease‒associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagySemantic proximity Read ↗

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and humanSemantic proximity Read ↗

VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and FunctionSemantic proximity Read ↗

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration.Semantic proximity Read ↗

VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin.Semantic proximity Read ↗

Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B.Semantic proximity Read ↗

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