Article

Targeting Rab-RILPL Interactions as a Strategy to Downregulate Pathogenic LRRK2 in Parkinson’s Disease

2023-11-06

Abstract excerpt

<h4>ABSTRACT</h4> Familial Parkinson’s disease (PD) is frequently linked to multiple disease-causing mutations within Leucine-Rich Repeat Protein Kinase 2 (LRRK2), leading to aberrant kinase activity. Multiple pathogenic effects of enhanced LRRK2 activity have been identified including loss of cilia and centrosomal cohesion defects. When phosphorylated by LRRK2, Rab8a and Rab10 bind to phospho-specific RILPL effe...

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Literature Corpus work: 5506d9d6-23fe-5c6e-872c-c09d4bfefb12
DOI: 10.1101/2023.11.06.565863

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