Article
Local Ancestry at the Major Histocompatibility Complex Region is Not a Major Contributor to Disease Heterogeneity in a Multiethnic Lupus Cohort.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Apr 2024
Solomon Olivia, Lanata Cristina M, Adams Cameron, Nititham Joanne, Taylor Kimberly E, Chung Sharon A, Yazdany Jinoos, Dall'Era Maria, Pons-Estel Bernado A, Tusié-Luna Teresa, Tsao Betty, Morand Eric, Alarcón-Riquelme Marta E, Barcellos Lisa F, Criswell Lindsey A
Abstract excerpt
OBJECTIVE: Systemic lupus erythematosus (SLE) is an autoimmune disease resulting in debilitating clinical manifestations that vary in severity by race and ethnicity with a disproportionate burden in African American, Mestizo, and Asian populations compared with populations of European descent. Differences in global and local genetic ancestry may shed light on the underlying mechanisms contributing to these...
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