European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus.

doi:10.1002/art.24707

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Article

European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus.

Arthritis and rheumatism - 1 Aug 2009

Chung Sharon A, Tian Chao, Taylor Kimberly E, Lee Annette T, Ortmann Ward A, Hom Geoffrey, Graham Robert R, Nititham Joanne, Kelly Jennifer A, Morrisey Jean, Wu Hui, Yin Hong, Alarcón-Riquelme Marta E, Tsao Betty P, Harley John B, Gaffney Patrick M, Moser Kathy L, Manzi Susan, Petri Michelle, Gregersen Peter K, Langefeld Carl D, Behrens Timothy W, Seldin Michael F, Criswell Lindsey A

Abstract excerpt

OBJECTIVE: To determine whether genetic substructure in European-derived populations is associated with specific manifestations of systemic lupus erythematosus (SLE), including mucocutaneous phenotypes, autoantibody production, and renal disease. METHODS: SLE patients of European descent (n=1,754) from 8 case collections were genotyped for >1,400 ancestry informative markers that define a north-south gradient of...

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PMID: 19644962
DOI: 10.1002/art.24707
PMCID: PMC2739103

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