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Article

Patient ancestry significantly contributes to molecular heterogeneity of systemic lupus erythematosus.

JCI insight - 6 Aug 2020

Catalina Michelle D, Bachali Prathyusha, Yeo Anthony E, Geraci Nicholas S, Petri Michelle A, Grammer Amrie C, Lipsky Peter E

Abstract excerpt

Gene expression signatures can stratify patients with heterogeneous diseases, such as systemic lupus erythematosus (SLE), yet understanding the contributions of ancestral background to this heterogeneity is not well understood. We hypothesized that ancestry would significantly influence gene expression signatures and measured 34 gene modules in 1566 SLE patients of African ancestry (AA), European ancestry (EA),...

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Identifiers

PMID: 32759501
DOI: 10.1172/jci.insight.140380
PMCID: PMC7455079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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