Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus

29 Aug 2019

Abstract excerpt

Systemic lupus erythematous (SLE) is a heterogeneous autoimmune disease in which outcomes vary among different racial groups. Here, we aim to identify SLE subgroups within a multiethnic cohort using an unsupervised clustering approach based on the American College of Rheumatology (ACR) classification criteria. We identify three patient clusters that vary according to disease severity. Methylation association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Lymphoma Diagnosis and Treatment
Share to Systemic Lupus Erythematosus Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31467281
DOI: 10.1038/s41467-019-11845-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosusPMID 31467281Read ↗

Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signaturesSemantic proximity Read ↗

Ethnicity-specific transcriptomic variation in immune cells and correlation with disease activity in systemic lupus erythematosusSemantic proximity Read ↗

Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus.Semantic proximity Read ↗

Ethnicity-specific transcriptomic variation in immune cells and correlation with disease activity in systemic lupus erythematosusSemantic proximity Read ↗

Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: Identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAISemantic proximity Read ↗

Molecular subtypes explain lupus epigenomic heterogeneity unveiling new regulatory genetic risk variantsSemantic proximity Read ↗

Ethnicity-specific epigenetic variation in naïve CD4+ T cells and the susceptibility to autoimmunitySemantic proximity Read ↗

The Lupus Epigenome Relates to Genetics, Transcription and Serological Profiles with Dependency on Molecular Subtypes and Informs Drug DiscoverySemantic proximity Read ↗

Molecular pathways identified from single nucleotide polymorphisms demonstrate mechanistic differences in systemic lupus erythematosus patients of Asian and European ancestry.Semantic proximity Read ↗

DNA Methylation Profiling in Childhood-Onset Lupus Reveals Distinct Epigenetic Clusters and Suggests Epigenetic Drivers of Disease ActivitySemantic proximity Read ↗

Adults with systemic lupus exhibit distinct molecular phenotypes in a cross-sectional studySemantic proximity Read ↗

Ancestry-based differences in the immune phenotype are associated with lupus activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.