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Article

Expanded molecular detection of MPL codon p.W515 and p.S505N mutations in myeloproliferative neoplasms.

Journal of clinical laboratory analysis - 1 Dec 2023

Miller Eric W, Lamberson Celeste M, Akabari Ratilal R, Nasr Michel R, Sperber Steven M

Abstract excerpt

BACKGROUND: Patients negative for the JAK2 p.V617F somatic variant are frequently reflexed to testing for MPL exon 10 variants. Detection of these variants via multiplexed allele-specific PCR followed by fragment analysis has been previously published. The present study builds on this concept by improving the detection of the p.W515A variant, adding a second allele-specific primer to detect the p.W515R variant,...

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Identifiers

PMID: 38058281
DOI: 10.1002/jcla.24992
PMCID: PMC10756946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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