Article
MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients.
Blood - 15 Nov 2006
Pardanani Animesh D, Levine Ross L, Lasho Terra, Pikman Yana, Mesa Ruben A, Wadleigh Martha, Steensma David P, Elliott Michelle A, Wolanskyj Alexandra P, Hogan William J, McClure Rebecca F, Litzow Mark R, Gilliland D Gary, Tefferi Ayalew
Abstract excerpt
Recently, a gain-of-function MPL mutation, MPLW515L, was described in patients with JAK2V617F-negative myelofibrosis with myeloid metaplasia (MMM). To gain more information on mutational frequency, disease specificity, and clinical correlates, genomic DNA from 1182 patients with myeloproliferative and other myeloid disorders and 64 healthy controls was screened for MPL515 mutations, regardless of JAK2V617F...
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