Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis.

Blood - 15 Nov 2007

Chaligné Ronan, James Chloé, Tonetti Carole, Besancenot Rodolphe, Le Couédic Jean Pierre, Fava Fanny, Mazurier Fréderic, Godin Isabelle, Maloum Karim, Larbret Frédéric, Lécluse Yann, Vainchenker William, Giraudier Stéphane

Abstract excerpt

The MPL (W515L and W515K) mutations have been detected in granulocytes of patients suffering from certain types of primitive myelofibrosis (PMF). It is still unknown whether this molecular event is also present in lymphoid cells and therefore potentially at the hematopoietic stem cell (HSC) level...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD34
Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Megakaryocytes

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Primary Myelofibrosis

Share to Receptors, Thrombopoietin

Share to T-Lymphocytes

Source

Identifiers

PMID: 17709604
DOI: 10.1182/blood-2007-05-089003

Genes

MPL
EPO
TPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17709604-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis.PMID 17709604Read ↗

MPLW515L mutation in acute megakaryoblastic leukaemia.Semantic proximity Read ↗

New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition.Semantic proximity Read ↗

Different mutations of the human c-mpl gene indicate distinct haematopoietic diseases.Semantic proximity Read ↗

MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort.Semantic proximity Read ↗

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients.Semantic proximity Read ↗

The MPL mutation.Semantic proximity Read ↗

Extending Jak2V617F and MplW515 Mutation Analysis to Single Hematopoietic Colonies and B and T LymphocytesSemantic proximity Read ↗

A review on the functional characteristics of the c-Myeloproliferative Leukaemia (c-MPL) gene and its isoformsSemantic proximity Read ↗

Screening for MPL mutations in essential thrombocythemia and primary myelofibrosis: normal Mpl expression and absence of constitutive STAT3 and STAT5 activation in MPLW515L-positive platelets.Semantic proximity Read ↗

Development of a Real-Time qPCR Assay for Detection of Common MPL Mutations in Myeloproliferative Neoplasms (MPNS).Semantic proximity Read ↗

JAK2V617F Megakaryocytes Promote Hematopoietic Stem/Progenitor Cell Expansion in Mice Through Thrombopoietin/MPL Signaling.Semantic proximity Read ↗

Single-cell analysis of ploidy and the transcriptome reveals functional and spatial divergency in murine megakaryopoiesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.