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Article

MPL exon 10 mutations other than canonical MPL W515L/K mutations identified by in-house MPL exon 10 direct sequencing in essential thrombocythemia.

International journal of hematology - 1 May 2021

Sugimoto Yuka, Nagaharu Keiki, Ohishi Kohshi, Nakamura Maki, Ikejiri Makoto, Nakatani Kaname, Mizutani Minoru, Tamaki Shigehisa, Ikeda Takeshi, Tawara Isao, Katayama Naoyuki

Abstract excerpt

MPL exon 10 mutations are one of the driver mutations in essential thrombocythemia (ET) or myelofibrosis (MF). We have established an in-house MPL mutation analysis system, covering the entire region of MPL exon 10 by direct sequencing. Since 2009, MPL exon 10 mutation analysis has been performed for diagnosis of myeloproliferative neoplasms (MPN) without JAK2 V617F or CALR exon 9 mutations. So far, 11 cases of...

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PMID: 33770389
DOI: 10.1007/s12185-021-03134-6

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