Article
Detection of MPLW515L/K mutations and determination of allele frequencies with a single-tube PCR assay.
PloS one - 1 Jan 2014
Takei Hiraku, Morishita Soji, Araki Marito, Edahiro Yoko, Sunami Yoshitaka, Hironaka Yumi, Noda Naohiro, Sekiguchi Yuji, Tsuneda Satoshi, Ohsaka Akimichi, Komatsu Norio
Abstract excerpt
A gain-of-function mutation in the myeloproliferative leukemia virus (MPL) gene, which encodes the thrombopoietin receptor, has been identified in patients with essential thrombocythemia and primary myelofibrosis, subgroups of classic myeloproliferative neoplasms (MPNs). The presence of MPL gene mutations is a critical diagnostic criterion for these diseases. Here, we developed a rapid, simple, and cost-effective...
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