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Article

COLD-PCR and innovative microarray substrates for detecting and genotyping MPL exon 10 W515 substitutions.

Clinical chemistry - 1 Dec 2012

Brisci Angela, Damin Francesco, Pietra Daniela, Galbiati Silvia, Boggi Sabrina, Casetti Ilaria, Rumi Elisa, Chiari Marcella, Cazzola Mario, Ferrari Maurizio, Cremonesi Laura

Abstract excerpt

BACKGROUND: Myeloproliferative neoplasms (MPNs) include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Somatic mutations in exon 10 of the MPL (myeloproliferative leukemia virus oncogene) gene, mainly substitutions encoding W515 variants, have recently been described in a minority of patients with ET or PMF. We optimized analytically sensitive methods for detecting and...

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Source

Identifiers

PMID: 23065476
DOI: 10.1373/clinchem.2012.192708

Genes

MPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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