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Article

Clinical utility of routine MPL exon 10 analysis in the diagnosis of essential thrombocythaemia and primary myelofibrosis.

British journal of haematology - 1 Apr 2010

Boyd Elaine M, Bench Anthony J, Goday-Fernández Andrea, Anand Shubha, Vaghela Krishna J, Beer Phillip, Scott Mike A, Bareford David, Green Anthony R, Huntly Brian, Erber Wendy N

Abstract excerpt

Approximately 50% of essential thrombocythaemia and primary myelo-fibrosis patients do not have a JAK2 V617F mutation. Up to 5% of these are reported to have a MPL exon 10 mutation but testing for MPL is not routine as there are multiple mutation types. The ability to routinely assess both JAK2 a...

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Source

Identifiers

PMID: 20151976
DOI: 10.1111/j.1365-2141.2010.08083.x

Genes

MPL
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20151976-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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