Article
Screening for MPL mutations in essential thrombocythemia and primary myelofibrosis: normal Mpl expression and absence of constitutive STAT3 and STAT5 activation in MPLW515L-positive platelets.
European journal of haematology - 1 May 2010
Glembotsky Ana C, Korin Laura, Lev Paola R, Chazarreta Carlos D, Marta Rosana F, Molinas Felisa C, Heller Paula G
Abstract excerpt
OBJECTIVES: To evaluate the frequency of MPL W515L, W515K and S505N mutations in essential thrombocythemia (ET) and primary myelofibrosis (PMF) and to determine whether MPLW515L leads to impaired Mpl expression, constitutive STAT3 and STAT5 activation and enhanced response to thrombopoietin (TPO)...
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