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Article

Deep sequencing reveals double mutations in cis of MPL exon 10 in myeloproliferative neoplasms.

Haematologica - 1 Apr 2011

Pietra Daniela, Brisci Angela, Rumi Elisa, Boggi Sabrina, Elena Chiara, Pietrelli Alessandro, Bordoni Roberta, Ferrari Maurizio, Passamonti Francesco, De Bellis Gianluca, Cremonesi Laura, Cazzola Mario

Abstract excerpt

Somatic mutations of MPL exon 10, mainly involving a W515 substitution, have been described in JAK2 (V617F)-negative patients with essential thrombocythemia and primary myelofibrosis. We used direct sequencing and high-resolution melt analysis to identify mutations of MPL exon 10 in 570 patients with myeloproliferative neoplasms, and allele specific PCR and deep sequencing to further characterize a subset of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21228032
DOI: 10.3324/haematol.2010.034793
PMCID: PMC3069239

Genes

MPL
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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