Article
Towards an understanding of somatic hypermutation.
Current opinion in immunology - 1 Apr 2001
Jacobs H, Bross L
Abstract excerpt
How germinal center (GC) B cells diversify their rearranged immunoglobulin genes by somatic hypermutation is unknown. However, the GC-specific activation-induced cytidine deaminase has been identified as a key factor controlling two central GC-specific events: somatic hypermutation and class-switch recombination of immunoglobulin genes. This factor may function as a catalytic subunit of an RNA-editing complex or,...
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