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Article

Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η.

Scientific reports - 28 Jan 2020

Lerner Leticia K, Nguyen Thuy V, Castro Ligia P, Vilar Juliana B, Munford Veridiana, Le Guillou Morwenna, Mohammad Mahwish Mian, Vergé Véronique, Rosselli Filippo, Menck Carlos F M, Sarasin Alain, Aoufouchi Said

Abstract excerpt

Somatic hypermutation of immunoglobulin genes is a highly mutagenic process that is B cell-specific and occurs during antigen-driven responses leading to antigen specificity and antibody affinity maturation. Mutations at the Ig locus are initiated by Activation-Induced cytidine Deaminase and are equally distributed at G/C and A/T bases. This requires the establishment of error-prone repair pathways involving the...

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Identifiers

PMID: 31992747
DOI: 10.1038/s41598-020-58180-7
PMCID: PMC6987143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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