Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η.

doi:10.1038/s41598-020-58180-7

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Article

Large deletions in immunoglobulin genes are associated with a sustained absence of DNA Polymerase η.

Scientific reports - 28 Jan 2020

Lerner Leticia K, Nguyen Thuy V, Castro Ligia P, Vilar Juliana B, Munford Veridiana, Le Guillou Morwenna, Mohammad Mahwish Mian, Vergé Véronique, Rosselli Filippo, Menck Carlos F M, Sarasin Alain, Aoufouchi Said

Abstract excerpt

Somatic hypermutation of immunoglobulin genes is a highly mutagenic process that is B cell-specific and occurs during antigen-driven responses leading to antigen specificity and antibody affinity maturation. Mutations at the Ig locus are initiated by Activation-Induced cytidine Deaminase and are...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Amino Acid Substitution
Brazil
Case-Control Studies
DNA-Directed DNA Polymerase
Enzyme Activation
France
Gene Frequency
Genotype
Humans
Immunoglobulins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mutation

Sequence Deletion

Xeroderma Pigmentosum

Source

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Identifiers

PMID: 31992747
DOI: 10.1038/s41598-020-58180-7
PMCID: PMC6987143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-31992747-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.