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Article

Somatic hypermutation in immunity and cancer: Critical analysis of strand-biased and codon-context mutation signatures.

DNA repair - 1 Sept 2016

Steele Edward J

Abstract excerpt

For 30 years two general mechanisms have competed to explain somatic hypermutation of immunoglobulin (Ig) genes. The first, the DNA-based model, is focused only on DNA substrates. The modern form is the Neuberger "DNA Deamination Model" based on activation-induced cytidine deaminase (AID) and short-patch error-prone DNA repair by DNA Polymerase-η operating around AID C-to-U lesions. The other is an RNA-based...

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Identifiers

PMID: 27449479
DOI: 10.1016/j.dnarep.2016.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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