Somatic hypermutation in immunity and cancer: Critical analysis of strand-biased and codon-context mutation signatures.

doi:10.1016/j.dnarep.2016.07.001

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Article

Somatic hypermutation in immunity and cancer: Critical analysis of strand-biased and codon-context mutation signatures.

DNA repair - 1 Sept 2016

Steele Edward J

Abstract excerpt

For 30 years two general mechanisms have competed to explain somatic hypermutation of immunoglobulin (Ig) genes. The first, the DNA-based model, is focused only on DNA substrates. The modern form is the Neuberger "DNA Deamination Model" based on activation-induced cytidine deaminase (AID) and sho...

Topics

APOBEC Deaminases
Animals
Codon
DNA
DNA Repair
DNA, Neoplasm
DNA-Directed DNA Polymerase
Genes, Immunoglobulin
Humans
Immunity, Innate
Mutation
Neoplasms
RNA
RNA Editing
Reverse Transcription
Somatic Hypermutation, Immunoglobulin

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