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Article

A benchmark study on current GWAS models in admixed populations.

Briefings in bioinformatics - 22 Nov 2023

Yang Zikun, Cieza Basilio, Reyes-Dumeyer Dolly, Montesinos Rosa, Soto-Añari Marcio, Custodio Nilton, Tosto Giuseppe

Abstract excerpt

OBJECTIVE: The performances of popular genome-wide association study (GWAS) models have not been examined yet in a consistent manner under the scenario of genetic admixture, which introduces several challenging aspects: heterogeneity of minor allele frequency (MAF), wide spectrum of case-control ratio, varying effect sizes, etc. METHODS: We generated a cohort of synthetic individuals (N = 19 234) that simulates...

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Identifiers

PMID: 38037235
DOI: 10.1093/bib/bbad437
PMCID: PMC10689347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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