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Article

Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power.

Nature genetics - 1 Feb 2021

Atkinson Elizabeth G, Maihofer Adam X, Kanai Masahiro, Martin Alicia R, Karczewski Konrad J, Santoro Marcos L, Ulirsch Jacob C, Kamatani Yoichiro, Okada Yukinori, Finucane Hilary K, Koenen Karestan C, Nievergelt Caroline M, Daly Mark J, Neale Benjamin M

Abstract excerpt

Admixed populations are routinely excluded from genomic studies due to concerns over population structure. Here, we present a statistical framework and software package, Tractor, to facilitate the inclusion of admixed individuals in association studies by leveraging local ancestry. We test Tractor with simulated and empirical two-way admixed African-European cohorts. Tractor generates accurate ancestry-specific...

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Identifiers

PMID: 33462486
DOI: 10.1038/s41588-020-00766-y
PMCID: PMC7867648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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