Article
Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population.
Human molecular genetics - 15 Feb 2011
Kenny Eimear E, Kim Minseung, Gusev Alexander, Lowe Jennifer K, Salit Jacqueline, Smith J Gustav, Kovvali Sirisha, Kang Hyun Min, Newton-Cheh Christopher, Daly Mark J, Stoffel Markus, Altshuler David M, Friedman Jeffrey M, Eskin Eleazar, Breslow Jan L, Pe'er Itsik
Abstract excerpt
The potential benefits of using population isolates in genetic mapping, such as reduced genetic, phenotypic and environmental heterogeneity, are offset by the challenges posed by the large amounts of direct and cryptic relatedness in these populations confounding basic assumptions of independence. We have evaluated four representative specialized methods for association testing in the presence of relatedness; (i)...
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