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Article

Extending genome-wide association studies to admixed cohorts with high degrees of relatedness.

Nature genetics - 1 Aug 2026

Tan Taotao, Vergara-Lope Alejandra, Martínez-Magaña José Jaime, Shah Nirav N, Lin Yi-Sian, Yuan Kai, Berumen Jaime, Alegre-Díaz Jesus, Kuri-Morales Pablo, Tapia-Conyer Roberto, Gelenter Joel, Montalvo-Ortiz Janitza L, Zhou Wei, Torres Jason M, Atkinson Elizabeth G

Abstract excerpt

Admixed populations comprise a large portion of the human population worldwide, but are often excluded from genome-wide association studies (GWASs) due to analytic challenges. Our group developed Tractor, a local-ancestry-informed GWAS tool designed for admixed samples that produces accurate ancestry-specific effect sizes and boosts the discovery power to identify ancestry-enriched loci. However, Tractor operates...

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PMID: 42477114
DOI: 10.1038/s41588-026-02689-6
PMCID: PMC13411139

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