Convergent evolution of allele-specific gene expression that leads to non-small cell lung cancer in different human populations.

Abstract excerpt

Phenotypical innovations during evolution are caused by novel mutations, which are usually heterozygous at the beginning. The gene expressions on two alleles of these mutation sites are not necessarily identical, leading to flexible allele-specific regulation in cell systems. We retrieve the transcriptome data of normal and non-small cell lung cancer (NSCLC) tissues from 47 African Americans (AA) and 50 European...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Black or African American