Driver Mutations in Normal Airway Epithelium Elucidate Spatiotemporal Resolution of Lung Cancer

Abstract excerpt

Abstract Rationale Uninvolved normal-appearing airway epithelium has been shown to exhibit specific mutations characteristic of nearby non–small cell lung cancers (NSCLCs). Yet, its somatic mutational landscape in patients with early-stage NSCLC is unknown. Objectives To comprehensively survey the somatic mutational architecture of the normal airway epithelium in patients with early-stage NSCLC. Methods...

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