Article
An evolutionarily conserved mechanism that amplifies the effect of deleterious mutations in osteosarcoma.
Molecular genetics and genomics : MGG - 1 Mar 2022
Jiang Yankai, Ge Fuqun, Sun Guoyong, Wang Haibin
Abstract excerpt
Illustrating the molecular consequence of deleterious mutations is essential for bridging the gap between genotype and phenotype. In the cancer field, differential expression of the two alleles on heterozygous sites could directly reflect the effect of a mutation under certain trans environment. We retrieved transcriptomes of osteosarcoma and normal tissues in human and mouse. We defined tumor-specific...
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