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Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients.

Cancer research - 1 Aug 2025

Qin Na, Wang Zhoufeng, Xu Xianfeng, Xie Yuan, Chen Yingjia, Luo Wenxin, Tang Pan, Wang Xin, Bi Lingfeng, Gong Linnan, Li Zhe, Chen Congcong, Wang Kai, Guo Songwei, Zhao Zihuan, Xiang Jun, Zhu Meng, Jiang Yue, He Yuanlin, Dai Juncheng, Yin Rong, Wang Cheng, Hu Zhibin, Ma Hongxia, Li Weimin, Shen Hongbing

Abstract excerpt

Lung adenocarcinoma (LUAD) is a heterogeneous disease with substantial genomic differences between individuals of Chinese and European ancestries. Deciphering the timing of driver mutations may lead to insights into tumor evolution that can inform diagnostic and therapeutic approaches for LUAD. In this study, we conducted whole-genome sequencing on LUAD samples from 251 patients with Chinese ancestry to...

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Source

Identifiers

PMID: 40479597
DOI: 10.1158/0008-5472.CAN-24-1799

Genes

EGFR
RB1
SFTPA1
SFTPB
TERT
TP53

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