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Article

Lung adenocarcinomas without driver genes converge to common adaptive strategies through diverse genetic, epigenetic, and niche construction evolutionary pathways.

Medical oncology (Northwood, London, England) - 5 May 2024

Gatenby Robert A, Luddy Kimberly A, Teer Jamie K, Berglund Anders, Freischel Audrey R, Carr Ryan M, Lam Amanda E, Pienta Kenneth J, Amend Sarah R, Austin Robert H, Hammarlund Emma U, Cleveland John L, Tsai Kenneth Y, Brown Joel S

Abstract excerpt

Somatic evolution selects cancer cell phenotypes that maximize survival and proliferation in dynamic environments. Although cancer cells are molecularly heterogeneous, we hypothesized convergent adaptive strategies to common host selection forces can be inferred from patterns of epigenetic and genetic evolutionary selection in similar tumors. We systematically investigated gene mutations and expression changes in...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Identifiers

PMID: 38704802
DOI: 10.1007/s12032-024-02344-2
PMCID: PMC11070398

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