Article
Genomic landscape of lung adenocarcinoma in East Asians.
Nature genetics - 1 Feb 2020
Chen Jianbin, Yang Hechuan, Teo Audrey Su Min, Amer Lidyana Bte, Sherbaf Faranak Ghazi, Tan Chu Quan, Alvarez Jacob Josiah Santiago, Lu Bingxin, Lim Jia Qi, Takano Angela, Nahar Rahul, Lee Yin Yeng, Phua Cheryl Zi Jin, Chua Khi Pin, Suteja Lisda, Chen Pauline Jieqi, Chang Mei Mei, Koh Tina Puay Theng, Ong Boon-Hean, Anantham Devanand, Hsu Anne Ann Ling, Gogna Apoorva, Too Chow Wei, Aung Zaw Win, Lee Yi Fei, Wang Lanying, Lim Tony Kiat Hon, Wilm Andreas, Choi Poh Sum, Ng Poh Yong, Toh Chee Keong, Lim Wan-Teck, Ma Siming, Lim Bing, Liu Jin, Tam Wai Leong, Skanderup Anders Jacobsen, Yeong Joe Poh Sheng, Tan Eng-Huat, Creasy Caretha L, Tan Daniel Shao Weng, Hillmer Axel M, Zhai Weiwei
Abstract excerpt
Lung cancer is the world's leading cause of cancer death and shows strong ancestry disparities. By sequencing and assembling a large genomic and transcriptomic dataset of lung adenocarcinoma (LUAD) in individuals of East Asian ancestry (EAS; n = 305), we found that East Asian LUADs had more stable genomes characterized by fewer mutations and fewer copy number alterations than LUADs from individuals of European...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.