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Article

Differential Allele-Specific Expression Uncovers Breast Cancer Genes Dysregulated by Cis Noncoding Mutations.

Cell systems - 26 Feb 2020

Przytycki Pawel F, Singh Mona

Abstract excerpt

Identifying cancer-relevant mutations in noncoding regions is challenging due to the large numbers of such mutations, their low levels of recurrence, and difficulties in interpreting their functional impact. To uncover genes that are dysregulated due to somatic mutations in cis, we build upon the concept of differential allele-specific expression (ASE) and introduce methods to identify genes within an...

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PMID: 32078798
DOI: 10.1016/j.cels.2020.01.002
PMCID: PMC7457951

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