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Article

Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma.

Nature communications - 15 Dec 2023

Haga Yasuhiko, Sakamoto Yoshitaka, Kajiya Keiko, Kawai Hitomi, Oka Miho, Motoi Noriko, Shirasawa Masayuki, Yotsukura Masaya, Watanabe Shun-Ichi, Arai Miyuki, Zenkoh Junko, Shiraishi Kouya, Seki Masahide, Kanai Akinori, Shiraishi Yuichi, Yatabe Yasushi, Matsubara Daisuke, Suzuki Yutaka, Noguchi Masayuki, Kohno Takashi, Suzuki Ayako

Abstract excerpt

The mechanism underlying the development of tumors, particularly at early stages, still remains mostly elusive. Here, we report whole-genome long and short read sequencing analysis of 76 lung cancers, focusing on very early-stage lung adenocarcinomas such as adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma. The obtained data is further integrated with bulk and spatial transcriptomic data and...

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Identifiers

PMID: 38102134
DOI: 10.1038/s41467-023-43732-y
PMCID: PMC10724178

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Source receipt: pubmed, retrieved 7 Sept 2026.

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