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Article

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

17 Aug 2012

Abstract excerpt

Inflammation alters host physiology to promote cancer, as seen in colitis-associated colorectal cancer (CRC). Here, we identify the intestinal microbiota as a target of inflammation that affects the progression of CRC. High-throughput sequencing revealed that inflammation modifies gut microbial composition in colitis-susceptible interleukin-10-deficient (Il10(-/-)) mice. Monocolonization with the commensal...

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PMID: 22903521
DOI: 10.1126/science.1224820

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