The genomic landscape of 2,023 colorectal cancers.

doi:10.1038/s41586-024-07747-9

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Article

The genomic landscape of 2,023 colorectal cancers.

Nature - 1 Sept 2024

Cornish Alex J, Gruber Andreas J, Kinnersley Ben, Chubb Daniel, Frangou Anna, Caravagna Giulio, Noyvert Boris, Lakatos Eszter, Wood Henry M, Thorn Steve, Culliford Richard, Arnedo-Pac Claudia, Househam Jacob, Cross William, Sud Amit, Law Philip, Leathlobhair Maire Ni, Hawari Aliah, Woolley Connor, Sherwood Kitty, Feeley Nathalie, Gül Güler, Fernandez-Tajes Juan, Zapata Luis, Alexandrov Ludmil B, Murugaesu Nirupa, Sosinsky Alona, Mitchell Jonathan, Lopez-Bigas Nuria, Quirke Philip, Church David N, Tomlinson Ian P M, Sottoriva Andrea, Graham Trevor A, Wedge David C, Houlston Richard S

Abstract excerpt

Colorectal carcinoma (CRC) is a common cause of mortality1, but a comprehensive description of its genomic landscape is lacking2-9. Here we perform whole-genome sequencing of 2,023 CRC samples from participants in the UK 100,000 Genomes Project, thereby providing a highly detailed somatic mutational landscape of this cancer. Integrated analyses identify more than 250 putative CRC driver genes, many not previously...

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PMID: 39112709
DOI: 10.1038/s41586-024-07747-9
PMCID: PMC11374690

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BRCA1
IDH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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