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Article

Association between mutations in a thyX-hsdS.1 region and para-aminosalicylic acid resistance in Mycobacterium tuberculosis clinical isolates.

Emerging microbes & infections - 1 Dec 2023

Zeng Rong, He Lina, Zhang Baoyue, Hu Yangbo, Yu Jifang, Yang Shanshan, Gu Jing, Wu Zhilong, Deng Jiaoyu

Abstract excerpt

Although para-aminosalicylic acid (PAS) has been used to treat tuberculosis agent for decades, its mechanisms of resistance are still not thoroughly understood. Previously, sporadic studies showed that certain mutations in the thyX-hsdS.1 region caused PAS resistance in M. tuberculosis, but a comprehensive analysis is lacking. Recently, we found a G-10A mutation in thyX-hsdS.1 in a PAS-resistant clinical isolate,...

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Identifiers

PMID: 38029724
DOI: 10.1080/22221751.2023.2276339
PMCID: PMC10769527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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