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The T120P or M172V mutation on rv2172c confers high level para-aminosalicylic acid resistance in Mycobacterium tuberculosis.

Emerging microbes & infections - 1 Dec 2024

Xu Jin-Tian, Yu Ji-Fang, Cheng Tao, Feng Ao, Yang Ping, Gu Jing, Yu Hong-Jun, Deng Jiao-Yu

Abstract excerpt

Although para-aminosalicylic acid (PAS) has been used to treat tuberculosis for decades, mechanisms of resistance to this drug in Mycobacterium tuberculosis (M. tuberculosis) clinical isolates have not been thoroughly investigated. Previously, we found that decreased methylenetetrahydrofolate reductase (MTHFR) activity of Rv2172c led to increased sensitivity to antifolates in M. tuberculosis. In this study, we...

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Identifiers

PMID: 39023395
DOI: 10.1080/22221751.2024.2374030
PMCID: PMC11271092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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