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Mutations in the promoter region of methionine transporter gene metM (Rv3253c) confer para-aminosalicylic acid (PAS) resistance in Mycobacterium tuberculosis.

mBio - 14 Feb 2024

Zhang Yu, Wang Shiyong, Chen Xinchang, Cui Peng, Chen Jiazhen, Zhang Wenhong

Abstract excerpt

Tuberculosis (TB) is a significant global public health threat. Despite the long-standing use of para-aminosalicylic acid (PAS) as a second-line anti-TB drug, its resistance mechanism remains unclear. In this study, we isolated 90 mutants of PAS-resistant Mycobacterium tuberculosis (MTB) H37Ra in 7H11 solid medium and performed whole-genome sequencing, gene overexpression, transcription level comparison and amino...

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Identifiers

PMID: 38179948
DOI: 10.1128/mbio.02073-23
PMCID: PMC10865796

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